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副研究員

姓名 王博石 性別
專家類別
學歷 博士 職稱 副研究員,碩士生導師
聯系電話 021-34206043 電子郵箱 wbs137@126.com
通訊地址 上海市閔行區東川路800號文選醫學樓411室
個人簡介

王博石,博士,副研究員。2007年畢業于南京大學生命科學學院,獲理學學士學位;2012年畢業于北京協和醫學院,細胞生物學專業,獲理學博士學位。2012年進入上海市腫瘤研究所,癌基因及相關基因國家重點實驗室工作。主要從事蛋白質降解及相關調控蛋白在腫瘤發生發展中的作用研究。近年,先后主持國家自然科學基金2項,包括青年項目與面上項目各1項;主持上海交通大學醫工交叉研究基金1項;2017年入選上海市青年科技啟明星計劃和上海市衛生系統優秀青年人才培養計劃。以第一作者在Nature Communications, Molecular Carcinogenesis, Clinical Science等雜志發表論文6篇。

研究方向

蛋白質降解及相關調控蛋白在腫瘤發生發展中的作用


科研論文

1.    Boshi Wang; Aihui Ma; Li Zhang; Weilin Jin; Yu Qian; Guiqin Xu; Bijun Qiu; Zhaojuan Yang; Yun Liu; Qiang Xia; Yongzhong Liu, POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation, Nature Communications, 2015, 6: 8704 (第一作者)

2.    Boshi Wang; Yang Yang; Hai-Zhen Lu; Li Shang; Yu Zhang; Jiajie Hao; Zhizhou Shi; Xiaomin Wang; Yizhen Liu; Qimin Zhan; Xuemei Jia; Mingrong Wang, Inhibition of atypical protein kinase Cι induces apoptosis through autophagic degradation of β-catenin in esophageal cancer cells, Molecular Carcinogenesis, 2014, 53(7): 514-525 (第一作者)

3.    Boshi Wang; Yizhen Liu; Yang Yang; Yu Zhang; Jia-Jie Hao; Hai Yang; Xiao-Min Wang; Ziqiang Zhang; Qimin Zhan; Mingrong Wang, Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP, Clinical Science, 2013, 124(3): 203-214 (第一作者)

4.    Boshi Wang; Yang Yang; Hai Yang; Yizhen Liu; Jiajie Hao; Yu Zhang; Zhizhou Shi; Xuemei Jia; Qimin Zhan; Mingrong Wang, PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line, Cell Stress and Chaperones, 2013, 18(3): 359-366 (第一作者)

5.    Yu Qian; Boshi Wang; Aihui Ma; Li Zhang; Guiqin Xu; Qi Ding; Boshi Wang; Tiantian Jing; Lin Wu; Yun Liu; Zhaojuan Yang; Yongzhong Liu, USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells, Scientific Reports, 2016, 6: 33039 (并列第一作者)

6.    Yizhen Liu; Boshi Wang; Yanyi Jiang; Jian Cao; Jiajie Hao; Yu Zhang; Xin Xu; Yan Cai; Mingrong Wang, MCMs expression in lung cancer: implication of prognostic significance, Journal of Cancer, 2017, 8(18): 3641-3647 (并列第一作者)

7.    Jiabin Sun; Boshi Wang; Yun Liu; Li Zhang; Aihui Ma; Zhaojuan Yang; Yuhua Ji; Yongzhong Liu, Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression, Cancer Letters, 2014, 355(1): 25-33

8.    Jingyi Li; Yun Liu; Boshi Wang; Yingqian Xu; Aihui Ma; Feng Zhang; Chao Ge; Zhaojuan Yang; Jinjun Li; Yongzhong Liu, Myeloid TGF-β signaling contributes to colitis-associated tumorigenesis in mice, Carcinogenesis, 2013, 34(9): 2099-2108

9.    Yizhen Liu; Yanyi Jiang; Boshi Wang; Jiajie Hao; Li Shang; Tongtong Zhang; Jian Cao; Xin Xu; Qimin Zhan; Mingrong Wang, A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens, Cancer Cytopathology, 2014, 122(11): 833-841

10.  Shuguang Liu; Boshi Wang; Yanyi Jiang; Tongtong Zhang; Zhizhou Shi; Yang Yang; Yiling Yang; Xiaochun Wang; Dechen Lin; Yu Zhang; Hai Yang; Yan Cai; Qimin Zhan; Mingrong Wang, Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway, Molecular Cancer Research, 2011, 9(4): 390-402


科研項目

1.    國家自然科學基金面上項目,課題號:81672359,2017.01-2020.12

2.    國家自然科學基金青年項目,課題號:81301716,2014.01-2016.12

3.   上海市青年科技啟明星計劃,課題號:17QA1403700,2017.04-2020.03

4.   上海市衛生系統優秀青年人才培養計劃,課題號:2017YQ040,2017.07-2020.06

5.   上海交通大學醫工交叉研究基金,課題號:YG2017MS51,2018.01-2020.12


獲得專利
實驗室成員
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