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首頁 >科研隊伍 >研究員


姓名 陳豪燕 性別
學歷 博士 職稱 研究員
聯系電話 電子郵箱
通訊地址 上海市斜土路2200弄25號

1.    消化道腫瘤的表觀遺傳學修飾和信號通路

2.    胃腸道腫瘤癌前疾病的發生機制。

3.    消化道腫瘤分子分型


1.Yan T, Shen C, Jiang P, Yu C, Guo F, Tian X, Zhu X, Lu S, Han B, Zhong M, Chen J, Liu Q, Chen Y, Zhang J, Hong J, Chen H, Fang JY. Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling. Signal Transduct Target Ther. 2021;6(1):70. (共同通訊作者,IF=13.5)

2.Zhu X, Tian X, Ji L, Zhang X, Cao Y, Shen C, Hu Y, Wong JWH, Fang JY, Hong J, Chen H.A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients. NPJ Precis Oncol. 2021;5(1):7. doi: 10.1038/s41698-021-00142-x(通訊作者,IF=7.7)

3.Hong J, Guo F, Lu SY, Shen C, Ma D, Zhang X, Xie Y, Yan T, Yu T, Sun T, Qian Y, Zhong M, Chen J, Peng Y, Wang C, Zhou X, Liu J, Liu Q, Ma X, Chen YX, Chen H, Fang JY. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2020 Dec 14:gutjnl-2020-322780. doi: 10.1136/gutjnl-2020-322780. (共同通訊作者,IF=19.8)

4.Chen H, Zou TH, Xuan B, Yan Y, Yan T, Shen C, Zhao G, Chen YX, Xiao X, Hong J, Fang JY.

Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production. Signal Transduct Target Ther. 2020 Jul 8;5(1):121. doi: 10.1038/s41392-020-00237-0.(第一作者,IF=13.5)

5. Shen C, Xuan B, Yan T, Ma Y, Xu P, Tian X, Zhang X, Cao Y, Ma D, Zhu X, Zhang Y, Fang JY, Chen H, Hong J.m6A-dependent glycolysis enhances colorectal cancer progression. Mol Cancer. 2020 Apr 3;19(1):72. doi: 10.1186/s12943-020-01190-w. (共同通訊作者,IF=15.3)

6. Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, Zhong M, Chen J, Ge Z, Li X, Chen X, Cui Y, Chen Y, Zou W, Chen H, Hong J, Fang JY. LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 2019 Aug 2;10(1):3499. doi: 10.1038/s41467-019-11447-8. (共同通訊作者,IF=12.1)

7.      Yan TT, Ren LL, Shen CQ, Wang ZH, Yu YN, Liang Q, et al. miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer. Cancer Res. 2018;78(7):1751-65. (共同通訊作者,IF=9.13)

8.      Liang Q, Ma D, Zhu X, Wang Z, Sun TT, Shen C, et al. RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer. Clin Cancer Res. 2018;24(6):1473-85. (共同通訊作者,IF=10.2)

9.      Yu T, Guo F, Yu Y, Sun T, Ma D, Han J, et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell. 2017;170(3):548-63 e16. (共同通訊作者,IF=30.4.)

10.    Zhu X, Tian X, Yu C, Shen C, Yan T, Hong J, et al. A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Molecular cancer. 2016;15(1):60. (通訊作者,IF=15.2)

11.    Sun TT, He J, Liang Q, Ren LL, Yan TT, Yu TC, et al. LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer discovery. 2016;6(7):784-801. (共同通訊作者,IF=20.4)





(4)上海市青年東方學者(特聘教授)和跟蹤計劃, 2014年/2017年

(5)上海市教委“高峰高原計劃”, 2015年/2016年



姓名: 洪潔; 研究員





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