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研究員

姓名 段友容 性別
專家類別 中國抗癌協會納米腫瘤學專業委員會委員、中美納米醫學暨納米生物技術學會(CASNN)會員、中國微米納米技術學會高級會員、中國醫藥生物技術協會納米生物技術分會委員
學歷 博士 職稱 研究員
聯系電話 021-64437139 電子郵箱 yrduan@@shsci.org
通訊地址 上海市徐匯區斜土路2200弄25號
個人簡介

2002年6月畢業于四川大學,獲生物醫學工程學博士學位,隨后進入華西醫科大學藥學院進行博士后研究。2005年進入上海市腫瘤研究所癌基因及相關基因國家重點實驗室工作。具有多學科交叉研究背景,長期從事藥物載體及納米緩控釋給藥系統的研究,在納米藥物載體的設計和制備方面具有豐富的經驗和相關知識的積累。作為課題負責人先后在材料學、藥學和醫學領域承擔國家自然科學基金面上項目6項,作為課題副組長參加國家自然科學基金重點項目1項,作為主研人員參加國家973項目和863項目的研究工作。獲得四川省科技進步一等獎和三等獎各一項。在Advanced Functional Materials; ACS Nano; Biomaterials; Nanotoxicology; J. Biomed. Nanotech.; ACS Appl. Mater. & Inter.等國際主流期刊上發表論文100余篇。申請中國發明專利20項,獲得授權發明專利12項(已獲轉讓2項)。


研究方向

1.逆轉或降低腫瘤耐藥性藥物遞送系統設計及應用;

2.腫瘤靶向藥物(基因)載體設計以及抗腫瘤給藥系統的構建(緩控釋);

3.載藥超聲造影劑用于可視化治療;

4.溫敏復合凝膠給藥系統對腫瘤的治療;

5.生物標志物檢測。


科研論文

1.       Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan, Ying Sun. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478. (通訊作者)

2.       De Zhao, Zhihua Wu, Jian Yu, Hongzhi Wang, Yaogang Li, Yourong Duan. Highly sensitive microfluidic detection of carcinoembryonic antigen via a synergetic fluorescence enhancement strategy based on the micro/nanostructure optimization of ZnO nanorod arrays and in situ ZIF-8 coating. Chemical Engineering Journal. 2020, 383: 123230. (通訊作者)

3.       Jiali Zhang, Chuanrong Chen, Hao Fu, Jian Yu, Ying Sun, Hui Huang, Yuanjia Tang, Nan Shen, Yourong Duan. MicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector/Regulatory T Cells Balance. ACS Nano, 2020, 14, 4414-4429. (通訊作者)

4.       Qi Wang, Xiangyu Zhang, Ying Sun, Liting Wang, Li Ding, Wei-Hong Zhu, Wen Di, You-Rong Duan. Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer. Biomaterials. 2019, 22: 73-86. (通訊作者)

5.       Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan, Ying Sun. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065. (通訊作者)

6.       Hao Fu, Chongchong Miao, Yuanpeng Rui, Fenglin Hu , Ming Shen , Hong Xu , Chunfu Zhang , Yi Dong, Wenping Wang, Hongchen Gu, Yourong Duan. Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron oxide nanoparticles and its mechanism investigation. Biomaterials. 2019, 222: 119442. (通訊作者)

7.       Dong Yang, Liao Hongze, Fu Hao, Yu Jian, Guo Qian, Wang Qi, Duan Yourong. pH-Sensitive Shell-Core Platform Block DNA Repair Pathway To Amplify Irreversible DNA Damage of Triple Negative Breast Cancer. ACS Appl Mater Interfaces. 2019, 42: 38417-38428. (通訊作者)

8.       Qi Wang, Xiangyu Zhang, Hongze Liao, Ying Sun, Li Ding, Yanwei Teng, Wei-Hong Zhu, Zhirong Zhang, Yourong Duan. Multifunctional Shell–Core Nanoparticles for Treatment of Multidrug Resistance Hepatocellular Carcinoma.  Advanced Functional Materials. 2018, 201706124 (通訊作者)

9.       Ying Sun, Qi Wang, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics, 2017, 7(18): 4424-4444. (通訊作者)

10.   Li Ding, Qi Wang, Ming Shen, Ying Sun, Xiangyu Zhang, Can Huang, Jianhua Chen, Rongxin Li, Yourong Duan. Thermoresponsive Nanocomposite Gel for Local Drug Delivery to Suppress the Growth of Glioma by Inducing Autophagy. Autophagy. 2017, 13(7): 1176-1190. (通訊作者)

11.   Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun, Xinyuan Liu, Yourong Duan. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560. (通訊作者)

12.   Can Huang, Ying Sun, Ming Shen, Xiangyu Zhang, Pei Gao, Yourong Duan. Altered Cell Cycle Arrest by Multifunctional Drug Loaded Enzymatically-Triggered Nanoparticles. ACS Applied Materials & Interfaces. 2016, 8: 1360?1370. (通訊作者)

13.   Wang Qi, Sun Ying, Zhang Zhirong, Duan Yourong. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. 2015, 56: 229-240. (通訊作者)

14.   Shen Ming, Xu Yuanyuan, Sun Ying, Han Baoshan, Duan Yourong. Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy. ACS Applied Materials & Interfaces. 2015, 7: 20530?20537. (通訊作者)

15.   Qi Wang, Peifeng Liu, Ying Sun, Tao gong, Xun Sun, Mingjie Zhu, Zhirong zhang, Yourong Duan. Preparation and properties of biocompatible PS-PEG/calcium phosphate nanospheres. Nanotoxicology, 2015, 9(2): 190-200. (通訊作者)

16.   Zelai He, Ying Sun, Qi Wang, Ming Shen, Mingjie Zhu, Fengqian Li, Yourong Duan. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL-Copolymer-Prepared Nanoparticles. Journal of Physical Chemistry C. 2015, 119(6): 3348-3362. (通訊作者)


科研項目

1. 國家自然科學基金面上項目,81972886,PRSS22介導的遞送系統實現多靶定向敲除克服非小細胞肺癌耐藥與轉移的研究

2. 國家自然科學基金面上項目,81773272,共載siRNA/PTX序貫釋放“雙管齊下”抗前列腺癌耐藥研究

3. 國家自然科學基金面上項目,81472841,磷脂/磷酸鈣殼核組裝序貫給藥克服腦膠質瘤細胞耐藥研究

4. 國家自然科學基金面上項目,81272568,兩相釋藥降低乳腺癌細胞耐藥靶向給藥系統的研究

獲得專利

1.      磷酸鈣和兩親性聚合物復合載藥納米微球、制備方法和用途. 中國,ZL200910198765.X

2.      聚乙二醇-聚乳酸羥基乙酸-聚賴氨酸納米遞送系統、制備方法及其應用. 中國,ZL200910247576.7

3.      用于治療腫瘤的藥物緩釋血管栓塞凝膠劑及其制備方法. 中國,ZL201110088056.3

4.      注射用整合素配體修飾的載藥腫瘤靶向陽離子聚合物. 中國,ZL200710039337.3

5.      雙腔微導管. 中國,ZL201620276998.2

6.      核殼結構聚合物/納米金復合納米材料及其制備方法和應用. 中國,ZL201210246282.4

7.      一種預防和治療前列腺炎穴位緩釋貼片及其制品、制備方法和用途. 中國,ZL200710043634.5

8.      脂質體硫酸鈣復合納米人工骨、制備方法和應用. 中國,ZL200910048164.0

9.      仿生磷脂聚合物細胞膜及其制備方法和用途. 中國,ZL200710129554.1

10.  腫瘤細胞及腫瘤血管雙靶向納米粒、構建方法及應用. 中國,ZL 201510503842.3

11.  一種治療膽系腫瘤的藥物納米復合溫敏凝膠劑. 中國,ZL201610046742.7

12.  一種復合顯影溫敏凝膠栓塞劑、制備方法及其應用. 中國,ZL201610207908.9

實驗室成員

工作人員

孫穎     副研究員(碩士生導師)    ysun@shsci.org

張佳利   助理研究員                jlzhang@shsci.org

張偉     助理研究員                wzhang@shsci.org

武志華   助理研究員                zhwu@shsci.org

余堅     副主任技師                yujian@shsci.org

田宇     助理研究員                ytian@shsci.org

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